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Sixty kinds of medicinal plants were examined upon the cytotoxicity against L1210 mouse leukemia cells. Isolation and purfication of effective antitumor substances from Chrysanthemum boreale had been performed which appeared strong cytotoxicity, In cytotoxicity test of the each solvent fractions, ED_(50) values of chloroform fraction against L1210, K562 and A549 cells were shown as 3.98, 4.28, 3.84 (㎍/㎖), respectively. Compound Ⅰ and Ⅱ were purified from the chloroform fraction. Between the purified compounds, ED_(50) values of Compound Ⅰ against L1210, K562 and A549 cells were shown as 0.55, 0.0003, 0.001 (㎍/㎖), respectively. Whereas Compound Ⅱ was shown as 4.79 against K562.
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